|
Symbol Name ID |
Spta1
spectrin alpha, erythrocytic 1 MGI:98385 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased mean corpuscular hemoglobin concentration |
Reticulocytosis |
Anemia |
Hemolytic anemia |
Spontaneous hemolytic crises |
Spherocytosis |
Increased red cell osmotic fragility |
Hypofibrinogenemia |
Hypercoagulability |
Extramedullary hematopoiesis |
Splenomegaly |
| Disease(s) Associated with SPTA1 | |||||||||||
| hereditary spherocytosis | |||||||||||
| hereditary spherocytosis type 3 |
| Mouse Phenotypes | increased B cell proliferation |
increased T cell proliferation |
enlarged spleen |
increased spleen weight |
abnormal erythropoiesis |
extramedullary hematopoiesis |
anemia |
hemolytic anemia |
hypochromic microcytic anemia |
microcytic anemia |
abnormal bone marrow cell number |
increased bone marrow cell number |
increased erythroid progenitor cell number |
erythroblastosis |
abnormal erythrocyte morphology |
decreased erythrocyte cell number |
low mean erythrocyte cell number |
decreased hematocrit |
decreased cellular hemoglobin content |
decreased hemoglobin content |
decreased mean corpuscular hemoglobin concentration |
decreased mean corpuscular volume |
increased mean corpuscular volume |
increased nucleated erythrocyte cell number |
abnormal red blood cell deformability |
anisocytosis |
anisopoikilocytosis |
elliptocytosis |
increased erythrocyte protoporphyrin level |
macrocytosis |
microcytosis |
poikilocytosis |
schistocytosis |
polychromatophilia |
spherocytosis |
increased neutrophil cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased T cell number |
increased lymphocyte cell number |
increased monocyte cell number |
increased leukocyte cell number |
reticulocytosis |
abnormal reticulocyte morphology |
abnormal spleen morphology |
decreased spleen iron level |
abnormal splenic cell ratio |
abnormal erythrocyte physiology |
increased erythrocyte clearance |
hemolysis |
abnormal erythrocyte osmotic lysis |
increased erythrocyte osmotic fragility |
increased IgA level |
increased IgG level |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1ihj/Spta1ihj | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-2Bc/Spta1sph-2Bc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-2J/Spta1sph-2J | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-3J/Spta1sph-3J | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-4J/Spta1sph-4J | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-Dem/Spta1sph-Dem | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-ha/Spta1sph-ha | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph/Spta1sph | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph-ha/Spta1+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spta1sph/Spta1+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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